2 glasses of juice consisting of the surrounding fruit and vegetables

Study on fasting & lifestyle adaptation in metabolic syndrome

Holger Cramer et al.

August 2022

Diet, Fasting & Detox

This study compared the efficacy and safety of fasting followed by lifestyle modification with lifestyle modification alone in patients with metabolic syndrome. The study involved 145 people whose results were assessed after 1, 12 and 24 weeks.

While there were no significant differences in co-primary outcomes at week 12, fasting resulted in significant reductions in several parameters, including HOMA index, blood pressure, BMI, weight, waist circumference, glucose, insulin, HbA1c, triglycerides, IL-6 and 10-year risk of acute coronary events compared to lifestyle modification alone at week 1.

Fasting also increased uric acid levels and slightly reduced eGRF. At week 24, significant group differences were found in weight, BMI, glucose, HDL and CRP. No serious adverse events occurred.

Fasting showed short-term benefits and may be considered as a lifestyle modification treatment in individuals with metabolic syndrome.

The most important information on the study at a glance

Indications: Metabolic syndrome
Institution: Department of Internal and Integrative Medicine, Evangelische Kliniken Essen-Mitte, University of Duisburg-Essen, 45276 Essen, Germany
Title: Study on the effect of fasting and lifestyle adaptation in metabolic syndrome
Brief description: The study shows that fasting reduces weight, blood pressure & other risk factors and is a good start to lifestyle change.
Original title: Effects of Fasting and Lifestyle Modification in Patients with Metabolic Syndrome: A Randomized Controlled Trial
Link to the study: https://pubmed.ncbi.nlm.nih.gov/36012990/