One hand holds a blood glucose meter pen while a finger of the other hand is prepared to take a blood sample. Sugar cubes can be seen out of focus in the foreground.

Study on Ayurvedic medicine BGR-34 for diabetes

Gaurav et al.

November 2020

Ayurveda medicine / treatment

Diabetes

This study focuses on BGR-34, a polyherbal formulation used to treat diabetes, particularly in Asian countries. However, since there is a lack of phytopharmacological studies on BGR-34, the compounds responsible for its antidiabetic and free radical scavenging activity were investigated.

The study investigated the in vitro inhibition of α-amylase and α-glucosidase enzymes by BGR-34 and its DPPH scavenging potential. High performance thin layer chromatography (HPTLC) and quantitative analysis were used to identify and quantify berberine and palmatine in BGR-34. In addition, TLC bioautography-mass spectrometry (MS) analysis was performed to identify the compounds responsible for the antidiabetic and antioxidant activities.

The results showed a significant and dose-dependent inhibition of the enzymatic reactions of α-amylase and α-glucosidase by BGR-34, along with a significant inhibition of the free radical scavenging activity of DPPH. HPTLC profiling confirmed the presence of berberine and palmatine in BGR-34, and TLC-MS bioautography revealed the presence of several bioactive compounds responsible for the antidiabetic and antioxidant activity.

Overall, the study suggests that BGR-34 contains various bioactive compounds responsible for its antidiabetic and antioxidant properties.

The most important information on the study at a glance

Indications: Diabetes
Institution: Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India
Title: Study on Ayurvedic medicine BGR-34 for diabetes
Brief description: The study shows that BGR-34 has significant antidiabetic and antioxidant effects and is suitable for the treatment of diabetes.
Original title: TLC-MS Bioautography-Based Identification of Free-Radical Scavenging, α-Amylase, and α-Glucosidase Inhibitor Compounds of Antidiabetic Tablet BGR-34
Link to the study: https://pubmed.ncbi.nlm.nih.gov/33251404/