Study on the effect of fasting on stress, ageing & metabolism

The University of Florida initiated a double-blind crossover study to investigate the effect of intermittent fasting (IF) on oxidative stress, aging and metabolism.

Since strict calorie restriction cannot be maintained for an extended period of time, the study used a modified approach of fasting (25% of normal calorie intake) and feasting (175% of normal calorie intake). The sample of 24 healthy volunteers underwent two three-week treatments, first IF and then the same with antioxidant supplementation (vitamins C and E).

Sirtuin levels increased marginally, plasma insulin levels decreased, but other markers of oxidative stress, ageing and metabolism did not change. The sample described the dietary requirements as tolerable and no adverse clinical findings were observed. The study thus suggests that IF is acceptable for healthy patients.