Study on Ayurvedic medicine BGR-34 for diabetes
Gaurav et al.
November 2020
Ayurveda medicine / treatment
Diabetes
This study focuses on BGR-34, a polyherbal formulation used to treat diabetes, particularly in Asian countries. However, since there is a lack of phytopharmacological studies on BGR-34, the compounds responsible for its antidiabetic and free radical scavenging activity were investigated.
The study investigated the in vitro inhibition of α-amylase and α-glucosidase enzymes by BGR-34 and its DPPH scavenging potential. High performance thin layer chromatography (HPTLC) and quantitative analysis were used to identify and quantify berberine and palmatine in BGR-34. In addition, TLC bioautography-mass spectrometry (MS) analysis was performed to identify the compounds responsible for the antidiabetic and antioxidant activities.
The results showed a significant and dose-dependent inhibition of the enzymatic reactions of α-amylase and α-glucosidase by BGR-34, along with a significant inhibition of the free radical scavenging activity of DPPH. HPTLC profiling confirmed the presence of berberine and palmatine in BGR-34, and TLC-MS bioautography revealed the presence of several bioactive compounds responsible for the antidiabetic and antioxidant activity.
Overall, the study suggests that BGR-34 contains various bioactive compounds responsible for its antidiabetic and antioxidant properties.
The most important information on the study at a glance
- Indications
- Diabetes
- Institution
- Bioactive Natural Product Laboratory, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India
- Title
- Study on Ayurvedic medicine BGR-34 for diabetes
- Brief description
- The study shows that BGR-34 has significant antidiabetic and antioxidant effects and is suitable for the treatment of diabetes.
- Original title
- TLC-MS Bioautography-Based Identification of Free-Radical Scavenging, α-Amylase, and α-Glucosidase Inhibitor Compounds of Antidiabetic Tablet BGR-34
- Link to the study
- https://pubmed.ncbi.nlm.nih.gov/33251404/
Suitable trips for this study topic
You might also be interested in
Ayurveda medicine / treatment
Naturopathy
Unnikrishnan Payyappallimana et al.
December 2020
Study shows the effectiveness of Ayurveda in treating epidemics and new conditions through holistic, natural approaches.
Abhimanyu Kumar, Asish Kumar Garai
October 2012
The study shows that Trikatrayadi Lauha doubles the hemoglobin level in children with iron deficiency in 10 weeks and has no side effects.
Ayurveda medicine / treatment
Mental health
Jessica M Gannon, et al.
May 2019
A study shows that ashwagandha extracts alleviate depression and anxiety in schizophrenia with few side effects.