Study on the effect of fasting in metabolic syndrome
András Maifeld et al.
March 2021
High blood pressure
Other fasting
The study investigates the effects of fasting and subsequent rebuilding on cardiometabolic risk, which is increased by the Western diet.
A substudy of NCT02099968 shows that in hypertensive patients with metabolic syndrome, a 5-day fast followed by a modified Dietary Approach to Stop Hypertension (DASH) diet reduces systolic blood pressure, the need for antihypertensive medication and body mass index after three months compared to a modified DASH diet alone. Fasting alters the gut microbiome and affects bacterial taxa and gene modules associated with short-chain fatty acid production. In addition, certain immune cells correlate with systolic blood pressure and body mass index. Machine analysis allows the prediction of a sustained systolic blood pressure response within the fasting group.
The high-resolution multi-omics data emphasize fasting as a promising non-pharmacological intervention for the treatment of hypertension in patients with metabolic syndrome.
The most important information on the study at a glance
- Indications
- Metabolic syndrome, high blood pressure
- Institution
- Experimental and Clinical Research Center, a joint cooperation of Max Delbruck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin, Berlin, Germany
- Title
- Study on the effect of fasting in metabolic syndrome
- Brief description
- The study shows that fasting followed by a DASH diet significantly lowers blood pressure and BMI in patients with metabolic syndrome.
- Original title
- Fasting alters the gut microbiome reducing blood pressure and body weight in metabolic syndrome patients
- Link to the study
- https://pubmed.ncbi.nlm.nih.gov/33785752/
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