Study on the anti-inflammatory effect of curcumin

Jessica Hoppstädter et al.

October 2016

Ayurveda

The 2016 study investigates the role of GILZ (glucocorticoid-induced leucine zipper) in attenuating inflammation and its potential as a therapeutic target. It examines the induction of GILZ by curcumin, a natural product known for its anti-inflammatory properties.

The study found that curcumin increases GILZ levels in macrophages by promoting translation and does not affect glucocorticoid receptor activation or mRNA stabilization. This effect is mediated by the mRNA-binding protein HuR, which binds to GILZ mRNA and promotes its translation.

Furthermore, experiments with mouse macrophages show that the anti-inflammatory effect of curcumin is accompanied by the induction of GILZ, leading to the inhibition of inflammatory regulators such as NF-κB and ERK and the subsequent reduction of TNF-α production.

Overall, the results suggest that the anti-inflammatory effect of curcumin is mediated, at least in part, by HuR-dependent GILZ induction.

The most important information on the study at a glance

Indications: Inflammations
Institution: Department of Pharmacy, Pharmaceutical Biology, Saarland University, 66041 Saarbrücken, Germany
Title: Study on the anti-inflammatory effect of curcumin
Brief description: The study shows that curcumin dampens inflammatory processes by increasing GILZ in macrophages & lowering the production of NF-κB and TNF-α.
Original title: Induction of Glucocorticoid-induced Leucine Zipper (GILZ) Contributes to Anti-inflammatory Effects of the Natural Product Curcumin in Macrophages
Link to the study: https://pubmed.ncbi.nlm.nih.gov/27629417/